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135k feature whole-genome microarray signaturechip® oligo solutiontm version 2.0  (Signature Genomic Laboratories LLC)

 
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    Structured Review

    Signature Genomic Laboratories LLC 135k feature whole-genome microarray signaturechip® oligo solutiontm version 2.0
    <t>Microarray</t> characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).
    135k Feature Whole Genome Microarray Signaturechip® Oligo Solutiontm Version 2.0, supplied by Signature Genomic Laboratories LLC, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/signaturechips/135k+feature+whole+genome+microarray+signaturechip++oligo+solutiontm+version+2+0/pmc04184748-30-11-23
    Average 90 stars, based on 1 article reviews
    135k feature whole-genome microarray signaturechip® oligo solutiontm version 2.0 - by Bioz Stars, 2026-10
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    Images

    1) Product Images from "Prenatal diagnosis of complex rearrangement of chromosome 21: The significance of interphase and metaphase fluorescence in situ hybridization and comparative genomic hybridization"

    Article Title: Prenatal diagnosis of complex rearrangement of chromosome 21: The significance of interphase and metaphase fluorescence in situ hybridization and comparative genomic hybridization

    Journal: Clinical Case Reports

    doi: 10.1002/ccr3.22

    Microarray characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).
    Figure Legend Snippet: Microarray characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).

    Techniques Used: Microarray, Control

    Related Articles

    Microarray:

    Article Title: Identification of cryptic imbalance in phenotypically normal and abnormal translocation carriers.
    Article Snippet: .. To determine the sizes of 1p36 deletions, microarray-based comparative genomic hybridization (array CGH) was performed on subjects 55 and 70 as previously described14 using a microarray constructed from 97 clones from a minimal tiling path of the most distal 10.5 Mb of 1p36.10 Microarray analysis for subject 63 was performed at Signature Genomic Laboratories, LLC (Spokane, WA, USA) using the SignatureChips (Figure 1). ..

    Hybridization:

    Article Title: Identification of cryptic imbalance in phenotypically normal and abnormal translocation carriers.
    Article Snippet: .. To determine the sizes of 1p36 deletions, microarray-based comparative genomic hybridization (array CGH) was performed on subjects 55 and 70 as previously described14 using a microarray constructed from 97 clones from a minimal tiling path of the most distal 10.5 Mb of 1p36.10 Microarray analysis for subject 63 was performed at Signature Genomic Laboratories, LLC (Spokane, WA, USA) using the SignatureChips (Figure 1). ..

    Construct:

    Article Title: Identification of cryptic imbalance in phenotypically normal and abnormal translocation carriers.
    Article Snippet: .. To determine the sizes of 1p36 deletions, microarray-based comparative genomic hybridization (array CGH) was performed on subjects 55 and 70 as previously described14 using a microarray constructed from 97 clones from a minimal tiling path of the most distal 10.5 Mb of 1p36.10 Microarray analysis for subject 63 was performed at Signature Genomic Laboratories, LLC (Spokane, WA, USA) using the SignatureChips (Figure 1). ..

    Clone Assay:

    Article Title: Identification of cryptic imbalance in phenotypically normal and abnormal translocation carriers.
    Article Snippet: .. To determine the sizes of 1p36 deletions, microarray-based comparative genomic hybridization (array CGH) was performed on subjects 55 and 70 as previously described14 using a microarray constructed from 97 clones from a minimal tiling path of the most distal 10.5 Mb of 1p36.10 Microarray analysis for subject 63 was performed at Signature Genomic Laboratories, LLC (Spokane, WA, USA) using the SignatureChips (Figure 1). ..



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    <t>Microarray</t> characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).
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    Image Search Results


    Microarray characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).

    Journal: Clinical Case Reports

    Article Title: Prenatal diagnosis of complex rearrangement of chromosome 21: The significance of interphase and metaphase fluorescence in situ hybridization and comparative genomic hybridization

    doi: 10.1002/ccr3.22

    Figure Lengend Snippet: Microarray characterization of a complex rearrangement of chromosome 21. Microarray plot showing (1) a two-copy gain of 25 oligonucleotide probes from the long arm of chromosome 21 at 21q11.2, ˜220 kb in size; immediately followed by (2) a single-copy gain of 285 oligonucleotide probes from 21q11.2-21q21.1, ˜2.74 Mb in size; immediately followed by (3) a two-copy gain of 85 oligonucleotide probes from 21q21.1, ˜860 kb in size. Also present are (4) a single-copy gain of 107 oligonucleotide probes from 21q21.1, ˜1.35 Mb in size; (5) a single-copy loss of 153 oligonucleotide probes from 21q21.3q-21q22.11, ˜3.77 Mb in size; (6) a single-copy gain of 483 oligonucleotide probes from 21q22.12.-21q22.2, ˜5.21 Mb in size; and (7) a single-copy gain of 528 oligonucleotide probes from terminal 21q22.2-21q22.3, ˜5.89 Mb in size. Probes are ordered on the x -axis according to physical mapping positions, with the most proximal q-arm probes to the left and the most distal q-arm probes to the right. Values along the y -axis represent log2 ratios of patient:control signal intensities. Results are visualized using Genoglyphix® (Signature Genomics, Spokane WA).

    Article Snippet: The analysis of aCGH of the umbilical cord specimen, using a 135K feature whole-genome microarray (SignatureChip® Oligo SolutionTM version 2.0, custom designed by Signature Genomic Laboratories, LLC, made by Roche NimbleGen®, Madison, WI) identified a complex rearrangement of 21q; six gains including DSCR and one loss, resulting in both partial trisomy 21q and partial monosomy 21q (Fig. ).

    Techniques: Microarray, Control